論文

花岡　健二郎

1~20件（全167件）

Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule.

著者名: Matsumoto K, Suzuki K, Magi M, Onishi S, Yoshida H, Takeshita M, Kuramoto J, Yazawa M, Kato T, Shimizu H, Ito T, Yamada S, Sasaki E, Hanaoka K, Noguchi-Sasaki M, Matsumoto Y, Takeuchi T, Kaneko Y
掲載誌名: 誌名Rheumatology (Oxford, England) 巻64(号8) 開始ページ4766 - 終了ページ4775 (出版年（月日）2025年03月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1462-0324

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DOI1

PubMed

M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

著者名: Komiyama S, Kodaira Y, Maeda R, Sugiura Y, Suzuki K, Saeki A, Kinashi Y, Oguchi H, Takano K, Onawa S, Matsui A, Sasaki E, Hattori-Muroi K, Kimura S, Fujimura Y, Ka Y, Ogura T, Hanaoka K, Ito M, Watarai H, Kaisho T, Udagawa N, Takahashi D, Hase K
掲載誌名: 誌名Proceedings of the National Academy of Sciences of the United States of America 巻123(号2) 開始ページe2506550123 (出版年（月日）2026年01月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 0027-8424

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DOI1

PubMed

Near-infrared (NIR)-responsive activation of Ru-benziphthalocyanine complexes via singlet-triplet transition

著者名: Takayama, O; Toriumi, N; Hanaoka, K; Uchiyama, M
掲載誌名: 誌名CHEMICAL SCIENCE 巻17(号19) 開始ページ9600 - 終了ページ9608 (出版年（月日）2026年05月）
ISSN: 2041-6520

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DOI1

PubMed

Recent advances in near-infrared dye conjugates for near-infrared photoimmunotherapy (NIR-PIT): enhancing therapeutic efficacy and immune mechanisms

著者名: Fuse, Y; Sasaki, E; Takayama, O; Yamada, S; Hanaoka, K
掲載誌名: 誌名RSC CHEMICAL BIOLOGY (出版年（月日）2026年06月）
ISSN: 2633-0679

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DOI1

PubMed

Visualizing Newly Synthesized Proteins and Their Degradation Dynamics by Using Long-Wavelength-Emitting Fluorescent Dye-DBCO Conjugates

著者名: Sumitani, S; Sasaki, E; Ohno, H; Yamada, S; Takayama, O; Wei, FY; Kuchitsu, Y; Taguchi, T; Hanaoka, K
掲載誌名: 誌名BIOCONJUGATE CHEMISTRY 巻37(号5) 開始ページ922 - 終了ページ929 (出版年（月日）2026年05月）
ISSN: 1043-1802

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DOI1

PubMed

Development of reactive sulfur species-producing enzyme inhibitors by fluorescent probe-based screening

著者名: Hanaoka, K
掲載誌名: 誌名FREE RADICAL BIOLOGY AND MEDICINE (出版年（月日）2026年06月）
ISSN: 0891-5849

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DOI1

Rapid Visualization of Deeply Located Tumors In Vivo by Intravenous Administration of a gamma-Glutamyltranspeptidase-Activated Fluorescent Probe

著者名: Nakada Akihiro, Maruyama Takuma, Kamiya Mako, Hanaoka Kenjiro, Urano Yasuteru
掲載誌名: 誌名BIOCONJUGATE CHEMISTRY 巻33(号3) 開始ページ523 - 終了ページ529 (出版年（月日）2022年03月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1043-1802

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DOI1

PubMed

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

著者名: Hanaoka Kenjiro, Iwaki Shimpei, Yagi Kiyoshi, Myochin Takuya, Ikeno Takayuki, Ohno Hisashi, Sasaki Eita, Komatsu Toru, Ueno Tasuku, Uchigashima Motokazu, Mikuni Takayasu, Tainaka Kazuki, Tahara Shinya, Takeuchi Satoshi, Tahara Tahei, Uchiyama Masanobu, Nagano Tetsuo, Urano Yasuteru
掲載誌名: 誌名JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 巻144(号43) 開始ページ19778 - 終了ページ19790 (出版年（月日）2022年10月）
役割: 筆頭著者責任著者
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 0002-7863

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PubMed

Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

著者名: Echizen, H; Hanaoka, K; Shimamoto, K; Hibi, R; Toma-Fukai, S; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Tsuchiya, Y; Watanabe, Y; Otsuka, T; Saito, H; Nagatoishi, S; Tsumoto, K; Kojima, H; Okabe, T; Shimizu, T; Urano, Y
掲載誌名: 誌名SCIENTIFIC REPORTS 巻13(号1) 開始ページ16456 (出版年（月日）2023年09月）
役割: 責任著者
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 2045-2322

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DOI1

PubMed

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

著者名: Hanaoka, K; Ikeno, T; Iwaki, S; Deguchi, S; Takayama, K; Mizuguchi, H; Tao, F; Kojima, N; Ohno, H; Sasaki, E; Komatsu, T; Ueno, T; Maeda, K; Kusuhara, H; Urano, Y
掲載誌名: 誌名SCIENCE ADVANCES 巻10(号7) 開始ページeadi8847 (出版年（月日）2024年02月）
役割: 筆頭著者責任著者
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 2375-2548

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DOI1

PubMed

Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging

著者名: Ohno, H; Sasaki, E; Yamada, S; Hanaoka, K
掲載誌名: 誌名ORGANIC & BIOMOLECULAR CHEMISTRY 巻22(号16) 開始ページ3099 - 終了ページ3108 (出版年（月日）2024年04月）
役割: 最終著者責任著者
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1477-0520

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DOI1

PubMed

Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition

著者名: Ukegawa, T; Komatsu, T; Minoda, M; Matsumoto, T; Iwasaka, T; Mizuno, T; Tachibana, R; Sakamoto, S; Hanaoka, K; Kusuhara, H; Honda, K; Watanabe, R; Urano, Y
掲載誌名: 誌名ADVANCED SCIENCE 巻11(号10) 開始ページe2306559 (出版年（月日）2024年03月）
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り

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DOI1

PubMed

Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing

著者名: Sakamoto, DM; Tamura, I; Yi, B; Hasegawa, S; Saito, Y; Yamada, N; Takakusagi, Y; Kubota, SI; Kobayashi, M; Harada, H; Hanaoka, K; Taki, M; Nangaku, M; Tainaka, K; Sando, S
掲載誌名: 誌名ACS NANO 巻18(号6) 開始ページ5167 - 終了ページ5179 (出版年（月日）2024年02月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1936-0851

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DOI1

PubMed

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors

著者名: Hirabayashi, K; Sasaki, E; Ohno, H; Takayama, O; Yamada, S; Hanaoka, K
掲載誌名: 誌名FRONTIERS IN PHYSIOLOGY 開始ページ1764165 (出版年（月日）2026年02月）
ISSN: 1664-042X

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DOI1

PubMed

Development of a near-infrared fluorescence probe for hypochlorous acid based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism

著者名: Ohno, H; Sumitani, S; Chuluun-Erdene, A; Kuchimaru, T; Yamada, S; Sasaki, E; Hanaoka, K
掲載誌名: 誌名CHEMICAL COMMUNICATIONS 巻61(号57) 開始ページ10522 - 終了ページ10525 (出版年（月日）2025年07月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1359-7345

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DOI1

PubMed

Heat-guided drug delivery via thermally induced crosslinking of polymeric micelles

著者名: Yamada, S; Sasaki, E; Ohno, H; Hanaoka, K
掲載誌名: 誌名COMMUNICATIONS CHEMISTRY 巻7(号1) 開始ページ287 (出版年（月日）2024年12月）
共著区分: 共著
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 2399-3669

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DOI1

PubMed

Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial O-Acetylserine Sulfhydrylase CysK and CysM

著者名: Rahman, A; Ono, K; Toyomoto, T; Hanaoka, K; Sawa, T
掲載誌名: 誌名INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 巻26(号3) (出版年（月日）2025年02月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1661-6596

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DOI1

PubMed

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

著者名: Kasai, T; Fujita, K; Komatsu, T; Ueno, T; Kojima, R; Hanaoka, K; Urano, Y
掲載誌名: 誌名RSC CHEMICAL BIOLOGY 巻6(号3) 開始ページ449 - 終了ページ456 (出版年（月日）2025年03月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 2633-0679

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DOI1

PubMed

SPATIAL TRANSCRIPTOMICS REVEAL THE ROLE OF MMP12 IN THE PATHOGENESIS OF GIANT CELL ARTERITIS

著者名: Onishi, S; Yoshida, H; Magi, M; Kato, C; Matsumoto, K; Suzuki, K; Takeshita, M; Kuramoto, J; Yazawa, M; Kato, T; Yamada, S; Sasaki, E; Hanaoka, K; Akiyama, M; Kondo, Y; Kikuchi, J; Kaneko, Y
掲載誌名: 誌名ANNALS OF THE RHEUMATIC DISEASES 開始ページ383 - 終了ページ384 (出版年（月日）2025年06月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 0003-4967

関連リンク

DOI1

Recent advances in fluorogenic probes based on twisted intramolecular charge transfer (TICT) for live-cell imaging

著者名: Ohno, H; Sumitani, S; Sasaki, E; Yamada, S; Hanaoka, K
掲載誌名: 誌名CHEMICAL COMMUNICATIONS 巻61(号69) 開始ページ12871 - 終了ページ12884 (出版年（月日）2025年08月）
掲載種別: 研究論文（学術雑誌）
査読有無: 有り
ISSN: 1359-7345

論文

花岡 健二郎

Trans-omics landscape of systemic vasculitis identified matrix metalloproteinase 12 as a novel signature molecule.

M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

Near-infrared (NIR)-responsive activation of Ru-benziphthalocyanine complexes via singlet-triplet transition

Recent advances in near-infrared dye conjugates for near-infrared photoimmunotherapy (NIR-PIT): enhancing therapeutic efficacy and immune mechanisms

Visualizing Newly Synthesized Proteins and Their Degradation Dynamics by Using Long-Wavelength-Emitting Fluorescent Dye-DBCO Conjugates

Development of reactive sulfur species-producing enzyme inhibitors by fluorescent probe-based screening

Rapid Visualization of Deeply Located Tumors In Vivo by Intravenous Administration of a gamma-Glutamyltranspeptidase-Activated Fluorescent Probe

General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process

Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation

A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)

Recent advances in Si-rhodamine-based fluorescent probes for live-cell imaging

Thioester-Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single-Molecule Enzyme Activities of Esterases with Specified Substrate Recognition

Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors

Development of a near-infrared fluorescence probe for hypochlorous acid based on the phenyl-induced twisted intramolecular charge transfer (p-TICT) mechanism

Heat-guided drug delivery via thermally induced crosslinking of polymeric micelles

Identification of Fungal Metabolite Gliotoxin as a Potent Inhibitor Against Bacterial O-Acetylserine Sulfhydrylase CysK and CysM

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

SPATIAL TRANSCRIPTOMICS REVEAL THE ROLE OF MMP12 IN THE PATHOGENESIS OF GIANT CELL ARTERITIS

Recent advances in fluorogenic probes based on twisted intramolecular charge transfer (TICT) for live-cell imaging

花岡　健二郎