著書

Supramolelular Design for Biological Applications The surface layer of the cell membrane plays important roles in interactions between the cells and their surroundings, e.g., other cells, soluble biological molecules, and extracelluar matrices (Figure 17.1). Cellular recognition is usually initiated by direct contact with biologically functional molecules at the cell surfaces. The mechanical stress stimulates cell activation in some circumstances. Specific interactions between receptors and ligands are important for cellular recognition. In many cases, multivalent binding (multivalency) can strengthen the ligand-receptor adhesion. In intercellular communication, accessory receptors are often required to stabilize the interaction by increasing the overall strength of the cell-cell adhesion, and co-receptors help activate cells by generating their own intracellular signals. Different combinations of receptors are likely to form complexes that transmit signals across membranes.

微粒子にDNAを固定化することにより遺伝子診断のデバイスとしての応用を試みた。

様々な微粒子を作製して、生体成分の固定化を行い、その生体認識能を用いて別の生体成分の分離を行うというシステムを開発した。

ナノ蛍光体の開発と応用

高分子微粒子の最新情報、特に生医学分野についての記述を担当

プラズマを用いた材料改質方法の概論