著書

Biomaterials and Drug Delivery toward New Millennium

生体非吸収性高分子からなる微粒子の作製と特徴

Encyclopedia of Biocolloid and Biointerface Science: Volume 1-2 This chapter first describes characteristics of a lipid membrane found in diverse biological systems and potentials of a lipid vesicle, a liposome, as a fundamental component of biomaterials. Then we describe the design and the synthesis of bioderived nanocapsules, namely, a liponanocapsule, by the creation of a functional capsule wall over the liposomal template. The layer-by-layer deposition of polyelectrolytes over the liposome made it possible to create liponanocapsules with a variety of polymeric walls. The nanocapsules exhibited fascinating properties and functions such as mechanical robustness, controlled release of various substances, and enhanced cell permeability, which originated from the capsule wall and the lipid membrane. We also focus on the assembly from liponanocapsules into a freestanding membrane, which is expected to be applicable as a bioscaffold for gene delivery and tissue engineering. Furthermore, we present the diffusion-controlled deposition of inorganic minerals by utilization of liponanocapsules as templates for mineralization. Thickness and crystal properties of hybrid organic–inorganic nanocapsules were tunable with the counterdiffusion of ions across the capsule wall.

遺伝子工学MOOK　 再生医療へのブレイクスルー　 ―医学から医療へ―必要なものと今後の方向 第2章　材料、技術、方法論の研究開発、 1.足場材料と関連技術2)基材表面が細胞の形に与える影響、