著書

During the past 70 years, a relationship between low-density lipoprotein cholesterol (LDL-C) and coronary heart disease (CHD) incidence has been established in many countries. Evidence of causality has been provided by the prevention of CHD by reduction of LDL-C, most notably with statins. These findings have made it possible to develop risk assessment charts for CHD and to detect high-risk individuals for early intervention. However, a causal relation between lipids and stroke, an adverse effect on noncoronary mortality such as that due to intraparenchymal hemorrhage, and the roles of lipid parameters other than LDL-C remain controversial.