研究テーマ

ナメクジウオ、ホヤ、ヒトはそれぞれ、頭索動物、尾索動物、脊椎動物に属し、これらは発生過程において脊索や、背側神経管と鰓孔、肛門より後方に伸びる尾など、共通のボディープランをもつ。このような共通の特長はどのようにしてつくられるのであろうか。脊索動物の発生過程は卵割期、胞胚期、原腸陥入期、神経板期、神経胚期、尾芽胚期といった共通の発

Purpose of the Research Project Different region of central nervous system, fore brain, mid brain, hind brain and spinal cord originates from one neural tube at organogenesis period. Defects of neural tube formation cause severe diseases, including anencephaly and spina bifida. While understanding of differentiation at the molecular level has been deepened, the molecular mechanism of the morphogenesis of neural tubes at different regions remains to be clarified. One of chordate, ascidian a