論文

a designed 2-phenylquinoline-estradiol hybrid effectively and selectively degraded the target transcription factor, human estrogen receptor-alpha, which has a high affinity with the estradiol moiety, under long-wavelength UV photo-irradiation, without additives and under neutral conditions.

An innovative method for target-selective degradation of oligosaccharides induced by a light-activated hybrid molecule consisting of anthraquinone and lectin has been developed. The reaction takes place under neutral conditions, and no additives are required.

The application of an efficient glycosylation methodology using 2,3-unsaturated sugards to synthesize critical precursors required for the total synthesis of an antibiotic, Vineomycin B2, was demonstrated.

Sulfated zirconia (SO4/ZrO2) catalyzed Mannich-type reaction of ketene silyl acetals and aldimines proceeded smoothly at room temperature to afford b-amino esters in good to high yields. In addition, the heterogeneous solid acid catalyst SO4/ZrO2 was easily recovered from the reaction mixture and then reused without significant loss of effectiveness.

Aryl C-glycosylation of several glycosyl donors, including unprotected sugars, with phenol and naphthol derivatives in an ionic liquid containing a protic acid proceeded effectively and stereoselectively to give the corresponding aryl C-glycosides in good to high yields. Because the ionic liquid was nonvolatile, the reaction could be carried out under reduced pressure; in addition, the ionic liquid could be reused without loss of effectivelness. The features contribute to the significant advantages of this novel aryl C-glycosylation reaction.

The newly designed and synthesized artificial anthracene derivatives possessing a deoxyamino sugar effectively and randomly cleaved proteins, such as bovine serum albumin (BSA) and hen egg lysozyme (Lyso), during photoirradiation using a long wavelength UV light (365 nm) without any further additives. Furthermore, it was found that the cleaving ability of anthracene could be improved by the attachment of a suitable substitute into anthracene core skeleton.