論文

© Springer Science+Business Media, LLC, part of Springer Nature 2018. Cardiotoxicity from cancer drugs remains a clinical problem. To find reliable markers of cardiotoxicity, animal models were proposed and potential new diagnostic, markers have been actively investigated using these models. Here we describe our protocols, using male Sprague-Dawley rats, for inducing cardiomyopathy by single injection of high-dose doxorubicin (5–10, mg/kg) or multiple injections (2–4 times) of low-dose doxorubicin (2.5, mg/kg) with combined single injection of trastuzumab (10, mg/kg). The cardiotoxicity is evaluated by imaging modalities (echocardiography and nuclear imaging), serum troponin levels, and histopathological analyses.

Introduction: It remains controversial whether moderator band (MB) originating from right ventricular outflow tract (RVOT) might be an arrhythmogenic substrate of idiopathic ventricular tachyarrhythmias originating in the RVOT (RVOT-VAs). Methods: We enrolled 17 patients (52.7 ±15.7 year-old, 5 men) with RVOT-VAs who underwent contrast-mediated multidetector computed tomography (MDCT) followed by successful ablation using CARTO X-P, and examined an anatomical relationship between the successful ablation site (the origin of RVOT-VAs) and the location of MB. Results: The successful ablation was obtained at anterior/lateral/posterior free wall and anterior/middle/posterior septum in 1/1/3/2/8/2 patients, respectively. The distance calipering between pulmonary valve annulus and the origin ranged between -10 and 18 mm (4.8±7.3). MB bridging the anterior and/or posterior attachment of RVOT was observed In 14 patients, but was away from the origin except 3 patients. Presystolic potential preceding the onset of VAs was detected in 5 patients (free wall in 1 patient and septum in 4 patients) who had no MB near the origin. Conclusion: MB is commonly located in anterior and posterior attachment below the origin of RVOT-VAs, and does not appear to be an arrhythmogenic substrate for RVOT-VAs in most patients. The presence of presystolic potential on VAs is not indicative of MB as the origin. © 2011, Japanese Heart Rhythm Society. All rights reserved.