Long-Term Depression at Parallel Fiber–Purkinje Cell Synapses
著者名
：Yuzaki M.
出版社
：Essentials of Cerebellum and Cerebellar Disorders: A Primer For Graduate Students, Second Edition
Long-term depression (LTD) at parallel fiber (PF)–Purkinje cell (PC) synapses plays an important role in cerebellar oculomotor control and classical conditioning. Climbing fiber inputs represent an error signal to generate specific temporal and spatial Ca2+ dynamics at PC spines leading to endocytosis of postsynaptic AMPA receptors at PF synapses during LTD induction.
