In an international collaborative study, a research team has analyzed multiple institutions that have successfully created hepatobiliary cancer organoids in order to study the success rate and environmental factors necessary for the successful establishment of such organoids. They also presented an outlook on information related to current issues, potential solutions, and future improvements in establishing hepatobiliary cancer organoids. The team was composed of Professor Yoshimasa Saito from the Faculty of Pharmacy at Keio University and researchers from Johns Hopkins University in the United States, the University of Cambridge in the United Kingdom, and the Erasmus University Medical Center in the Netherlands. The results of this research were published online in the international journal Cancer Cell on February 2, 2022 (EST).