In a joint study with the Shizuoka University, the Shizuoka Prefectural Fisheries and Marine Technology Research Institute focused on Substance A, based on the screening results of specific fish-derived substances. First, in vitro experiments confirmed that Substance A has a HIF-inhibiting effect. Next, in experiments using laser-induced choroidal neovascularization (CNV) mice, a model for age-related macular degeneration, it was found that Substance A reduces the area of CNV. Furthermore, qPCR analysis revealed that Substance A suppresses the expression of inflammatory factors such as IL-6. These results suggest that Substance A has the potential to be a new therapeutic agent for age-related macular degeneration.
Applicable regions
Shizuoka prefecture
Implementation period
October, 2019 - present
Community and Regional Affairs category
Regional collaboration as research targets and implementation sites/research that aims to popularize region-specific issues
Related websites
Related agreements, etc.
Seeds creation research work centered on marine biotechnology
Cooperating institutions, etc.
Shizuoka Prefectural Research Institute of fishery and Marine
Fuculty of Agriculture, Shizuoka University
Campus
Shinanomachi
Person in charge
Toshihide Kurihara, MD/PhD
Inquiries
kurihara.z8@keio.jp