Kawano, Yoshinaga
カワノ ヨシナガ
Kawano, Yoshinaga
School of Medicine Department of Internal Medicine (Nephrology, Endocrinology and Metabolism)/Assistant ProfessorBasic Information
Researcher Number
80571463
Biography
Researcher profile
My main research interest is immunometabolism especially in intestinal immunity in the pathophysiology of insulin resistance. My master’s thesis is the role of Foxo1 in Macrophage in glucose metabolism. I clarified that Foxo1 in macrophage induced Ccr2 expression and deteriorated Visceral Adipose Tissue (VAT) inflammation and systemic Insulin resistance (Kawano Y et al. Diabetes. 2012). After graduate school, he became interested in gut immunity in HFD induced insulin resistance, because he found that pro-inflammatory macrophages infiltrate into colon earlier than into VAT. He currently reported that colonic pro-inflammatory macrophage could play important roles in the mechanism of HFD induced insulin resistance (Kawano Y et al. Cell metabolism. 2016)
Research experience
Residency: Keio University Hospital, JPN Keio University Hospital Residency
Fellowship: Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology Keio University Hospital, JPN Division of Endocrinology, Metabolism, Nephrology Fellowship
Assistant Professor, Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology Keio University School of Medicine, JPN. Division of Endocrinology, Metabolism, Nephrology Assistant Professor
Research
Research Interests
- Insulin Resistance
- Diabetes
- Immuno-metabolism
- Intestinal Immunity
Research areas
Immunology
Metabolism and endocrinology
Research theme
糖・エネルギー代謝における免疫細胞Foxoの役割
Physiological roles of gut immunity in high fat diet induced insulin resistance