May 27, 2025
Keio University School of Medicine
Keio University Hospital
A research team from the Eisai-Keio University Dementia Innovation Laboratory (EKID), composed of Project Professor Daisuke Ito of the Department of Neurology, Keio University School of Medicine / Memory Center, Keio University Hospital, and researcher Misato Kaishima of Eisai Co., Ltd., has developed a Polygenic Risk Score (PRS) model that can predict the risk of amyloid-β accumulation in the brain. The model was constructed using data from a Japanese dementia cohort and the results of a genome-wide association study of Alzheimer's disease in Japanese individuals. The team has demonstrated that by utilizing this PRS, it is possible to predict the risk of amyloid-β accumulation in the brain, which is involved in the onset of Alzheimer's disease in the Japanese population.
These research findings suggest the possibility of understanding an individual's inherent risk of developing Alzheimer's disease, which is expected to lead to increased awareness of prevention before onset, as well as to early diagnosis and treatment. This research was published online in the international medical journal Alzheimer's Research & Therapy on May 22, 2025.
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