Director: Shigeru Koh (Associate Professor, School of Medicine)
Main Campus: Shinanomachi
Center Overview
The "Center for Systems Medical Engineering Research and Development" organizes cross-faculty research teams from the School of Medicine, Faculty of Science and Technology, and Faculty of Environment and Information Studies. In cooperation with participating companies, we develop technologies to build a next-generation medical ICT platform that enables the comprehensive integration, sharing, and analysis of medical information. We also develop medical and healthcare systems that contribute to further extending the nation's healthy life expectancy by maximizing the use of large volumes of medical information obtained through comprehensive molecular and imaging analysis technologies for individual healthcare. We will disseminate these results to the world and contribute to the realization of a vibrant and ideal society of centenarians with a healthy 100-year lifespan.
Keywords and Main Research Themes
Healthy longevity, society of centenarians, next-generation medical ICT platform, genomic medicine, systems medicine
Fiscal Year 2019 Business Plan
■Continuing Activities from FY2018: Background, Rationale, and Goals
In FY2019, we will continue our shared research for the AMED "Project for Innovative Drug Discovery Technology through Glycan Utilization." We will also continue preparations to begin the operational use of the specimen management system within FY2019 (Shigeru Koh).
Telemedicine is finally entering the stage of social implementation as a form of healthcare. Telemedicine is a medical modality highly compatible with the databasing of medical information, and through its promotion, I hope to contribute to facilitating the construction of a next-generation medical ICT platform (Taishiro Kishimoto).
We have achieved many results from our past research. In FY2019, we will continue to promote the development of new test items, research to select new test items and confirm their clinical utility, and collaborative research with various clinical departments, including laboratory medicine (Mitsuru Murata).
By leveraging various mass spectrometry technologies in our department, we will clarify the metabolic characteristics of cancer cells and immune cells, and continue to identify the "points of action" for their respective metabolic remodeling (Takehiro Yamamoto).
■New Activity Goals and Content for FY2019, and Implementation Background
In FY2019, we will continue our activities to introduce the specimen management system at Keio University Hospital (Shigeru Koh).
We will continue the development of the glycan analysis system (Shigeru Koh).
I will become a member of the preparatory committee for telemedicine in the psychiatric field and will make adjustments for its social implementation (Taishiro Kishimoto).
The School of Medicine and the hospital are working together on the university's specimen banking system. We will prepare the laboratory side to handle its actual operation (Mitsuru Murata).
Based on this fiscal year's research results, we have identified multiple specific molecular vibration signals in cancerous or non-cancerous areas from Raman spectroscopic analysis using clinical specimens. In FY2019, we will proceed with the identification of these molecules and aim to expand our analysis to search for marker molecules that correlate with the success of chemotherapy (Takehiro Yamamoto).
Fiscal Year 2019 Business Report
■Implementation Details for the Fiscal Year Business Plan, Research Outcomes, and Degree of Achievement
Introduction and operation of the specimen management system at Keio University Hospital: We are preparing to introduce the program developed in FY2015 at Keio University Hospital for use in actual clinical settings. In FY2019, we held monthly meetings of the Specimen Management Support Division Working Group and prepared for the future introduction of the specimen management system at Keio Hospital.
Glycan analysis research: We are conducting research for the FY2017 "Project for Innovative Drug Discovery Technology through Glycan Utilization" by the Japan Agency for Medical Research and Development (AMED), specifically for R&D Proposal (1) "Construction of a Multifaceted Glycan Analysis System for Target Molecule Discovery and Verification, Leveraging Japan's Technological Strengths and Close Industry-Academia-Medical Collaboration" (Principal Investigator: Kō-u Sakamoto). Keio University is one of the two core research institutes for this project, along with AIST (Tsukuba) and the Keio University School of Medicine, and plays a crucial role in the clinical application of this project. We continued our research activities in FY2019 (Shigeru Koh).
Commissioned research from the Japan Agency for Medical Research and Development (AMED) on telepsychiatry: We conducted research for the ICT Infrastructure Development for Clinical Research Project, Medical Digital Revolution Realization Project, on "Guideline Development and Database Construction for Data Utilization through the Accumulation of Clinical Research Evidence in Telepsychiatry" (Taishiro Kishimoto).
Development of new test items, selection of new test items, research to confirm clinical utility, and collaborative research with various clinical departments including laboratory medicine: We provide research support through the creation of test data and specialized knowledge. Research results were obtained and disseminated both domestically and internationally in areas such as the development of sample collection methods and information management systems for clinical research; practical testing methods for minimal residual disease in malignant tumors and their efficiency and standardization; automation and standardization of urinalysis; development and dissemination of POCT (point-of-care testing); promotion of domestic and international external quality control and quality assurance; quantitative analysis of DNA methylation by LC-MS/MS; development of urinary steroid metabolite analysis; and microbial genetic diagnostic methods, especially the development of fully automated genetic testing equipment (Mitsuru Murata).
Metabolome analysis research: This fiscal year, we revealed that the sulfur-containing amino acid metabolite hypotaurine contributes to the oxidative stress resistance of colon cancer cells. We also established a detection system for hydrogen persulfide, which also acts as an electrophile within tumors. Using various cell lines and clinical specimens, we are investigating the metabolic profiles of cancerous and non-cancerous areas through trans-omics technology that combines metabolome analysis using CE-MS, expression analysis of metabolic enzyme groups, and imaging technology for sulfur-containing compounds using Raman microscopy. We are exploring the novel effects of sulfur-containing compounds in the acquisition of malignant traits in cancer (Takehiro Yamamoto).
Achievements in Social Contributions, including Published Papers, Conference Presentations, and Events
Published papers: 6
J Telemed Telecare, J Affect Disord, et al.
Number of conference presentations (domestic/international): 29 (24 domestic, 5 international)
Achievements in social contributions such as events
"Initiatives for AI Utilization in Psychiatry," Medical x AI Seminar Series, June 15, 2019, 6th Symposium "Implementation and Trust of Medical AI in Clinical Practice," Tokyo, The University of Tokyo, International Academic Research Building 4F, SMBC Academia Hall
"Progress in Introducing Telepsychiatry and Guideline Development, and an Attempt to Quantify Psychiatric Symptoms Using Machine Learning," July 10, 2019, 21st Century Medical Forum, 4th Healthcare Subcommittee Meeting, Tokyo, TKP Shinbashi Conference Center Annex
"Prospects for Innovation in the Psychiatric Field Using Information and Communication Technology and Machine Learning," September 27, 2019, Yamanashi Psychiatric Research Association Supporters' Meeting, Yamanashi, Yamanashi Prefectural Library, Multipurpose Hall
"IoT Healthy Life Research in a Super-Aged Society," December 13, 2019, The 20th KEIO TECHNO-MALL 2019, Tokyo, Tokyo International Forum
"Development of New Treatment Support and Prevention Technologies in the Psychiatric Field Utilizing Information and Communication Technology," January 31, 2020, FY2019 Symposium on the Project for Next-Generation Medical Device Collaboration Hub Facilities, etc., Tokyo, Station Conference Tokyo
Project Members
Principal Investigator
Shigeru Koh
Associate ProfessorThe Sakaguchi Laboratory (Systems Medicine), School of MedicineMasayuki Amagai
ProfessorDepartment of Dermatology, School of Medicine