KGRI Grant 2026: Development of eco-friendly fermentation technology based on microbial thermotolerance via chemical priming

This project aims to establish a novel strategy for enhancing microbial functions using Heat Shock Metabolites (HSMs) without relying on genetic modification.

We will develop a chemical priming technology that enhances both thermotolerance and metabolic activity of microorganisms through the application of HSMs. In addition, we will employ AI-assisted optimization to further refine and optimize the chemical priming strategy.

We will systematically evaluate the effects of HSMs on the thermotolerance and fermentation performance of industrial microorganisms, including yeasts and acetic acid bacteria.

We will then optimize combinations and application conditions of multiple HSMs to develop chemical priming conditions that maximize microbial performance.

Using Streptomyces as a model, we will investigate the molecular mechanisms underlying HSM-mediated thermotolerance, with a particular focus on transport, degradation, and cellular responses.

The outcomes of this study are expected to provide a foundation for improving high-temperature fermentation processes, reducing energy consumption, and advancing applications in fermentation industries and biomanufacturing.