Ishigaki, Kazuyoshi

Individual differences—or polymorphisms—in our genomic sequences are fundamental determinants of immune function. While recent research has linked specific polymorphisms to the development of immune-mediated diseases, the immense complexity of the immune system often masks the underlying biological mechanisms. Consequently, translating these genetic insights into successful 'genome-based drug discovery' remains a significant challenge. Our laboratory is dedicated to bridging this gap. By integrating cutting-edge technologies—including CRISPR genome editing, single-cell analysis, and multi-omics approaches—we aim to elucidate the functional roles of disease-risk polymorphisms and identify novel therapeutic targets for immune disorders.

We aim to elucidate the pathogenesis of autoimmune diseases and the underlying mechanisms of autoimmune responses through integrated analysis of big data such as multi-omics analysis. To achieve these objectives, we also aim to develop new experimental systems and analysis algorithms.