Published papers
OHE Tomoyuki
41-60 items (total 62)
A trapping method for semi-quantitative assessment of reactive metabolite formation using [35S]cysteine and [14C]cyanide.
- Author
- Inoue K, Shibata Y, Takahashi H, Ohe T, Chiba M, Ishii Y.
- Publication Title
- Magazine name Drug Metab Pharmacokinet Start Page 245-254 (Publication Date）2009/10）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Aromatic substitution reaction of 2-chloropyridines catalyzed by microsomal glutathione S-transferase 1.
- Author
- Inoue K, Ohe T, Mori K, Sagara T, Ishii Y, Chiba M.
- Publication Title
- Magazine name Drug Metab Dispos Start Page 1797-1800 (Publication Date）2009/09）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.
- Author
- Takahashi H, Haga Y, Shibata T, Nonoshita K, Sakamoto T, Moriya M, Ohe T, Chiba M, Mitobe Y, Kitazawa H, Iwaasa H, Ishihara A, Ishii Y, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Start Page 5436-5439 (Publication Date）2009/09）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Discovery of trans-N-[1-(2-fluorophenyl)-3-pyrazolyl]-3-oxospiro[6-azaisobenzofuran-1(3H),1'-cyclohexane]-4'-carboxamide, a potent and orally active neuropeptide Y Y5 receptor antagonist.
- Author
- Haga Y, Sakamoto T, Shibata T, Nonoshita K, Ishikawa M, Suga T, Takahashi H, Takahashi T, Takahashi H, Ando M, Murai T, Gomori A, Oda Z, Kitazawa H, Mitobe Y, Kanesaka M, Ohe T, Iwaasa H, Ishii Y, Ishihara A, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Start Page 6971-6982 (Publication Date）2009/09）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor.
- Author
- Ando M, Sato N, Nagase T, Nagai K, Ishikawa S, Takahashi H, Ohtake N, Ito J, Hirayama M, Mitobe Y, Iwaasa H, Gomori A, Matsushita H, Tadano K, Fujino N, Tanaka S, Ohe T, Ishihara A, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Start Page 6106-6122 (Publication Date）2009/08）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6:
- Author
- Shimamura K, Kitazawa H, Miyamoto Y, Kanesaka M, Nagumo A, Yoshimoto R, Aragane K, Morita N, Ohe T, Takahashi T, Nagase T, Sato N, Tokita S.
- Publication Title
- Magazine name J Pharmacol Exp Ther Start Page 249-256 (Publication Date）2009/07）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.
- Author
- Takahashi T, Haga Y, Sakamoto T, Moriya M, Okamoto O, Nonoshita K, Shibata T, Suga T, Takahashi H, Hirohashi T, Sakuraba A, Gomori A, Iwaasa H, Ohe T, Ishihara A, Ishii Y, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Start Page 3511-3516 (Publication Date）2009/07）
- Authorship Category
- Joint Work
- Publication Category
- Research paper (scientific journal)
- Peer-review Status
- With
Discovery of tetrasubstituted imidazolines as potent and selective neuropeptide Y Y5 receptor antagonists: reduced human ether-a-go-go related gene potassium channel binding affinity and potent antiobesity effect.
- Author
- Sato N, Ando M, Ishikawa S, Jitsuoka M, Nagai K, Takahashi H, Sakuraba A, Tsuge H, Kitazawa H, Iwaasa H, Mashiko S, Gomori A, Moriya R, Fujino N, Ohe T, Ishihara A, Kanatani A, Fukami T.
- Publication Title
- Magazine name J Med Chem Start Page 3385-3392 (Publication Date）2009/05）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.
- Author
- Ogino Y, Ohtake N, Nagae Y, Matsuda K, Moriya M, Suga T, Ishikawa M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Start Page 5010-5014 (Publication Date）2008/09）
- Authorship Category
- Joint Work
- Publication Category
- Research paper (scientific journal)
- Peer-review Status
- With
Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.
- Author
- Ogino Y, Ohtake N, Nagae Y, Matsuda K, Ishikawa M, Moriya M, Kanesaka M, Mitobe Y, Ito J, Kanno T, Ishihara A, Iwaasa H, Ohe T, Kanatani A, Fukami T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Start Page 4997-5001 (Publication Date）2008/09）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.
- Author
- Sato N, Jitsuoka M, Shibata T, Hirohashi T, Nonoshita K, Moriya M, Haga Y, Sakuraba A, Ando M, Ohe T, Iwaasa H, Gomori A, Ishihara A, Kanatani A, Fukami T.
- Publication Title
- Magazine name J Med Chem Start Page 4765-4770 (Publication Date）2008/08）
- Authorship Category
- Joint Work
- Publication Category
- Research paper (scientific journal)
- Peer-review Status
- With
A neuropeptide Y Y5 antagonist selectively ameliorates body weight gain and associated parameters in diet-induced obese mice.
- Author
- Ishihara A, Kanatani A, Mashiko S, Tanaka T, Hidaka M, Gomori A, Iwaasa H, Murai N, Egashira S, Murai T, Mitobe Y, Matsushita H, Okamoto O, Sato N, Jitsuoka M, Fukuroda T, Ohe T, Guan X, MacNeil DJ, Van der Ploeg LH, Nishikibe M, Ishii Y, Ihara M, Fukami T.
- Publication Title
- Magazine name Proc Natl Acad Sci U S A Start Page 7154-7158 (Publication Date）2006/05）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
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Blood-Brain Barrier Pharmacoproteomics-based Reconstruction of the In-Vivo Brain Distribution of P-glycoprotein Substrates in Cynomolgus Monkeys.
- Author
- Uchida Y, Wakayama K, Ohtsuki S, Chiba M, Ohe T, Ishii Y, Terasaki T.
- Publication Title
- Magazine name J Pharmacol Exp Ther Start Page 578-588 (Publication Date）2014/09）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation
- Author
- Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T.
- Publication Title
- Magazine name Bioorganic and Medicinal Chemistry Letters Volume 28(Issue 23-24) Start Page 3708 - End Page 3711 (Publication Date）2018/10）
- Authorship Category
- Joint Work
- Publication Category
- Research paper (scientific journal)
- Peer-review Status
- With
- ISSN
- 0960894X
Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor
- Author
- Yasuda, D., Yuasa, A., Obata, R., Nakajima M., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T., and Mashino, T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Volume 27(Issue 22) Start Page 5006 - End Page 5009 (Publication Date）2017/11）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity
- Author
- Yasuda, D., Nakajima, M., Yuasa, A., Obata, R., Takahashi, K., Ohe, T., Ichimura, Y., Komatsu, M., Yamamoto, M., Imamura, R., Kojima, H., Okabe, T., Nagano, T., and Mashino, T.
- Publication Title
- Magazine name Bioorg Med Chem Lett Volume 26(Issue 24) Start Page 5956 - End Page 5959 (Publication Date）2016/12）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
Potential suppressive effects of two C60-fullerene derivatives on acquired immunity
- Author
- Toshiro Hirai, Yasuo Yoshioka, Asako Udaka, Eiichiro Uemura, Tomoyuki Ohe, Hisae Aoshima, Jian-Qing Gao, Ken Kokubo, Takumi Oshima, Kazuya Nagano, Kazuma Higashisaka, Tadahiko Mashino, Yasuo Tsutsumi
- Publication Title
- Magazine name Nanoscale Research Letters Start Page 449 (Publication Date）2016/10）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
- Author
- Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M
- Publication Title
- Magazine name Nature Communications Volume 7(Issue 12030) Start Page 1 - End Page 16 (Publication Date）2016/06）
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- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
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A proline-type fullerene derivative inhibits adipogenesis by preventing PPARgamma activation
- Author
- Megumi Funakoshi-Tagoa, Takahiro Hattori, Fumihito Ueda, Kenji Tago, Tomoyuki Ohe, Tadahiko Mashino, Hiroomi Tamura
- Publication Title
- Magazine name Biochemistry and Biophysics Reports Volume 20(Issue 1) Start Page 258 - End Page 263 (Publication Date）2016/01）
- Authorship Category
- Joint Work
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- Research paper (scientific journal)
- Peer-review Status
- With
The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives
- Author
- Takumi Yasuno, Tomoyuki Ohe, Kyoko Takahashi, Shigeo Nakamura, Tadahiko Mashino
- Publication Title
- Magazine name Bioorg Med Chem Lett Volume 25(Issue 16) Start Page 3226 - End Page 3229 (Publication Date）2015/08）
- Authorship Category
- Joint Work
- Publication Category
- Research paper (scientific journal)
- Peer-review Status
- With