Arita, Makoto
アリタ マコト
Arita, Makoto
Faculty of Pharmacy Department of Pharmacy/ProfessorBasic Information
Researcher Number
80292952
Biography
General introduction
Our research is aimed at elucidating structure and function of endogenous lipid mediators that regulate inflammation and tissue homeostasis. Polyunsaturated fatty acid (PUFA)-derived mediators are formed by enzymatic oxidation through the action of cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 monooxygenases (CYP). By using LC-MS/MS-based lipidomics, we provided new insights into the cellular and molecular mechanisms of inflammatory resolution. Also, we have established a non-targeted lipidomics platform that enables us to identify the structural diversity of lipids in human and mouse tissues, cells, and commensal bacteria. The Lipidome Atlas project is ongoing by developing MS imaging techniques to visualize the effect of the local environment created by specific lipids on the dynamics and functions of multicellular systems. We aim to elucidate the mechanisms that create, regulate, and recognize lipid diversity and its localization in vivo, as well as to elucidate diseases caused by the disruption of such mechanisms.
Research experience
Keio University Human Biology Microbiome Quantum Research Center (Bio2Q) Core Director
Brigham&Women's Hospital / Harvard Medical School Instructor
Brigham&Women's Hospital / Harvard Medical School Postdoctoral Fellow
Research
Research Interests
- Lipidome Atlas
- Lipoquality
- Bioactive molecules
- Regulation of Inflammation
- Lipid Biochemistry
- Metabolomics
Research areas
Molecular biology
Functional biochemistry
Pharmaceutical hygiene and biochemistry
Medical biochemistry
Research theme
リピドームアトラスの創出
Genetic and lipidomic approach to understand anti-inflammatory property of omega-3 PUFAs
Mediator lipidomics in acute inflammation and resolution