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The rapid diagnosis of patients in clinical practice is important for anti-influenza therapy. However, since the sensitivity of conventional rapid diagnostic test kits is low, false-negative results are often produced. Therefore, simple and convenient test kits with high sensitivity are needed in clinical practice. In this chapter, we describe the construction of a boron-doped diamond (BDD) electrode that terminates with a receptor (sialic acid-containing oligosaccharide chain)-mimicking peptide as well as its performance in the electrochemical detection of human and avian influenza viruses (IFVs).