Published papers

To clarify the feeling of knowing a name but not being able to recall it, known as having a "tip-of-the-tongue" (TOT) experience, we proposed a TOT model consisting of three stages combining a face recognition model and autonomic sympathetic nerve activity. Since TOT increases with age, we compared two age groups: young (N = 27, M = 20.4 ± 1.5 years) and middle-aged (N = 29, M = 58.5 ± 8.0 years). Experiment 1 showed that successfully naming low-frequency common names increased the skin conductance response (SCR) value, and the time to reach the maximum SCR value was longer. Experiment 2 was a naming task for face photographs. The younger group showed higher SCR values during successfully naming, while the middle-aged group showed similar SCR values for successfully naming and experiencing TOT. Both groups had the longest time to reach maximum SCR in TOT. In this study, physiological arousal of TOT was not affected by aging.

BACKGROUND: Epidemiological studies have shown that dairy product consumption is beneficial for cognitive function in elderly individuals. β-lactolin is a Gly-Thr-Trp-Tyr lacto-tetrapeptide rich in fermented dairy products that improves memory retrieval, attention, and executive function in older adults with subjective cognitive decline and prevents the pathology of Alzheimer's disease in rodents. There has been no study on the effects of β-lactolin on neural activity in humans. OBJECTIVE: We investigated the effects of β-lactolin on neural activity and cognitive function in healthy adults. METHODS: In this randomized, double-blind, placebo-controlled study, 30 participants (45-64 years old) consumed β-lactolin or placebo for 6 weeks. Neural activity during auditory and language tasks was measured through 64-channel electroencephalography. Moreover, verbal fluency tests were performed at baseline and after 6 weeks. RESULTS: The β-lactolin group had a significantly higher P300 amplitude at the Cp2 site (a part of the parietal lobe near the center of brain, p = 0.011), and C4 site (the area between the frontal and parietal lobe, p = 0.02) during the auditory tasks after 6 weeks than the placebo group. Thus, β-lactolin supplementation promoted neural activity in the parietal area, which increases concentration and attention during auditory cognitive tasks. Compared with the placebo group, the β-lactolin group also showed significant changes in the scores of verbal fluency test after 6 weeks (p = 0.033). CONCLUSION: Our findings provide insight into the mechanisms underlying the effects of β-lactolin on attention in healthy adults.

急性痛が島皮質や背側前帯状皮質を中核とするセイリエンスネットワークとの関連が強い一方で,慢性一次性疼痛では,情動・感情に関連する部位の活性化が目立つ.予測処理/符号化モデルに則れば,恐怖と紐づいた痛み体験は,トップダウンの予測の重みづけを高め,実際の感覚入力とは不釣り合いに強い痛みの知覚をもたらす.疼痛再処理療法は,痛みに対する恐怖を,脳由来の無害な感覚であるという認識に変えることで高い鎮痛効果を示す.抑圧・抑制された感情の認識と表出を促す感情認識表出療法も,認知行動療法より高い鎮痛効果が報告されており,有望な心理療法である.(著者抄録)

Understanding mechanisms of intelligence of human beings and animals is one of the most important approaches to develop intelligent robot systems. Since the mechanisms of such real-life intelligent systems are so complex, physical interactions between agents and their environment and the social interactions between agents should be considered. Comprehension and knowledge in many peripheral fields such as cognitive science, developmental psychology, brain science, evolutionary biology, and robotics is also required. Discussions from an interdisciplinary aspect are very important for implementing this approach, but such collaborative research is time-consuming and labor-intensive, and it is difficult to obtain fruitful results from such research because the basis of experiments is very different in each research field. In the social science field, for example, several multi-agent simulation systems have been proposed for modeling factors such as social interactions and language evolution, whereas robotics researchers often use dynamics and sensor simulators. However, there is no integrated system that uses both physical simulations and social communication simulations. Therefore, we developed a simulator environment called SIGVerse that combines dynamics, perception, and communication simulations for synthetic approaches to research into the genesis of social intelligence. In this paper, we introduce SIGVerse, its example application and perspectives. ©2010 IEEE.

© 2019 Ito, Terasawa, Umeda and Kawaguchi. Episodic future simulation is supported by both the retrieval and recombination of episodic details. It remains unclear, however, how individuals retrieve episodic details from memory to construct possible future scenarios; for this people must use details related to the planned future events appropriately. A potentially relevant cognitive process is the spontaneous activation of intention observed in prospective memory (i.e., the intention superiority effect). Previous studies on prospective memory have shown that the approximation of retrieval opportunities for future intentions activate related information, suggesting that the intention superiority effect is context-sensitive. We hypothesized that the same cognitive process underlies future simulation-that is, details related to future events should spontaneously become activated at the appropriate moment of future simulation to make that simulation plausible. In Experiment 1, participants took part in future experiments and formed intentions to perform particular actions for the next experiments. Subsequently, they imagined events that could occur up until they arrived at the experimental room on the day of the next experiment. During this exercise, they did not imagine engaging in the required experimental task. We measured the conceptual activation of intention-related information via a recognition task using intended action words as targets. The results showed the intention superiority effect-concepts related to participants' future intentions became active when envisioning future events approaching the next experiment. In Experiments 2 and 3, we ensured that the intention superiority effect in future simulation was context-sensitive by adding a control condition that required participants to imagine events other than the approaching future experiments. These results indicated that concepts related to the intended actions were spontaneously activated when imagined future events became both temporally and spatially close to the future simulation. Our finding suggests that spontaneous activation of details approaching the context of a future simulation helps in constructing plausible future scenarios.

従来までに，社会エージェントシステムを用いて経済や言語進化などのシミュレーションが実現されてきている．一方で，ロボティクスでは物理法則に基づく運動や，視聴覚等のセンシングのシミュレーションに基づいて知能行動の研究が行われている．本稿ではこの双方のシミュレーションを同時に実行可能なシステムを構築し，人間とロボットエージェント間の身体性認知・運動を考慮した社会的知能の研究プラットフォームを提案する

Time estimation in patients with prefrontal cortex (PFC) damage is often inaccurate. The relationship between PFC and estimation of short time intervals has been examined. However, it remains unclear whether PFC damage affects estimation of longer time intervals. Here, we investigated the ability of patients and healthy subjects to verbally estimate a period of 30 min, using a method easily applied in clinical settings. In 99 patients with brain damage, we compared under and normal ranges of time in patients with PFC damage or damage to other brain areas with the chi-squared test. Subsequently, we conducted a discriminant analysis and a multiple linear regression analysis to identify specific brain areas affecting time estimation. We observed a significantly larger number of patients who overestimated 30 min in the group with bilateral PFC damage compared to patients with damage to other regions. Discriminant analysis revealed that damage of right lateral PFC and left medial PFC contributed to discrimination between the normal range and overestimation groups. Multiple linear regression analysis indicated that right lateral PFC damage strongly affected overestimation of a 30-min interval. Neuropsychological test results revealed lower general cognitive function scores and orientation scores in overestimation group. The length of estimated time and the score of delayed word recall were negatively correlated. We propose that these may require encoding, maintenance, and updating of memory and are indirectly related to contextual memory. We discuss hypotheses on contextual memory segmentation and reconstruction to clarify the mechanism of impaired time overestimation in PFC-damaged patients.

Prospective memory involves memory for future intentions in our everyday lives and it is one of the hot topics in current memory research. We reexamined what is prospective memory and discussed how intentions had been conceived of in the history of psychology. We emphasize the necessity of classifying a form of remembering intentions into the self-initiated existence-remembrance and its content-remembrance. Many studies on prospective memory in recent decades were reviewed with respect to the following perspectives: (1) how intentions are recollected, (2) what is remembering intentions based on, (3) how we attempt to avoid forgetting to do things, and (4) what is neuropsychological mechanism of remembering intentions. Requirements for experimental research on prospective memory are summarized and future directions are discussed.