December 23, 2022
Tokyo Women's Medical University
Keio University
A group led by Lecturer Hironobu Takahashi and Professor Tatsuya Shimizu of the Institute of Advanced Biomedical Engineering and Science at Tokyo Women's Medical University, in collaboration with a group led by Associate Professor Kenichi Nagase of the Faculty of Pharmacy at Keio University, has developed a technology to create a human skeletal muscle tissue model with high contractile force. Furthermore, by combining this with a system capable of quantitatively measuring contractile force, they have developed a technology that can decipher the effects of specific drugs on muscle from changes in contractile force.
Succeeded in creating a highly accurate human muscle tissue that structurally and functionally mimics living tissue.
Constructed a muscle tissue with high contractile force using a proprietary cell sheet stacking technology.
The muscle tissue model is compatible with a system that can quantitatively measure changes in muscle contraction.
The muscle tissue model can reproduce in vitro how muscle contractile force increases or decreases in response to drugs.
It is expected to be a useful muscle tissue model and contractile force measurement system for future drug discovery research on myopathies.
Please see below for the full press release.