2018/11/15
Asahikawa Medical University
Sapporo Higashi Tokushukai Hospital
Teine Keijinkai Hospital
Hokkaido University
Tohoku University
Tokyo Medical University
Keio University School of Medicine
Genomedia Inc.
Highlights of this Research
Elucidated the mechanism by which pancreatic cancer develops from pancreatic cysts.
Discovered a new pathway from benign lesions to cancer based on patterns of genetic abnormalities.
Expected to improve the accuracy of diagnosis for predicting the development of pancreatic cancer in patients with pancreatic cysts.
A research team led by Associate Professor Yusuke Mizukami of the Department of Internal Medicine at Asahikawa Medical University, Assistant Professor Yuko Omori of the Department of Tumor Pathology at Hokkaido University (currently the Department of Anatomic Pathology at Tohoku University), and Principal Investigator Yusuke Ono of the Medical Research Institute at Sapporo Higashi Tokushukai Hospital has discovered a new carcinogenesis pathway. In the formation of pancreatic cancer in patients with intraductal papillary mucinous neoplasm (IPMN), a type of tumorous cyst that forms in the pancreas, this pathway involves precursor lesions—which are in an intermediate state between benign and malignant—evolving by branching into lesions with diverse properties and characteristics.
The results of this research were published in the online edition of the American scientific journal "Gastroenterology" on October 17, ahead of their publication in the February 2019 issue.
Please see below for the full press release.