September 14, 2018
Keio University School of Medicine
Project Associate Professor Keiichi Hishikawa of the Endowed Department of iPS Cell Research and Epigenetic Medicine and Project Assistant Professor Taro Tsujimura of the Department of Physiology, at the Keio University School of Medicine and Graduate School of Medicine, have used cutting-edge genome editing technology to elucidate in detail the mechanism by which a protein called CTCF hierarchically controls the three-dimensional structure of DNA according to its specific binding patterns to genomic DNA.
Further development of this finding could enable the creation of a completely new technology for manipulating the three-dimensional structure of genomic DNA and gene function. This technology is expected to have wide-ranging applications, not only in regenerative medicine, drug development, and cancer treatment, but in many other fields as well.
The results of this research were published in the international epigenetics journal "Epigenetics & Chromatin" on September 14, 2018 (JST).
Please see below for the full press release.