August 21, 2018
National Cancer Center Japan
Tokyo Medical and Dental University
Kansai Medical University
Keio University School of Medicine
Japan Agency for Medical Research and Development (AMED)
Highlights of this research
We have pioneered the world in clarifying the characteristics of gene mutations in lung adenocarcinoma complicated by interstitial pneumonia.
We found that mutations that cause a loss of function in a group of genes involved in lung formation and function are frequently observed in lung adenocarcinoma complicated by interstitial pneumonia.
This is expected to lead to the elucidation of the pathology of lung adenocarcinoma complicated by interstitial pneumonia and the development of new therapeutic methods.
A research team led by Division Chief Takashi Kohno of the Division of Genome Biology, National Cancer Center Research Institute (Director: Hiroyuki Mano), National Cancer Center Japan (President: Hitoshi Nakagama, Chuo-ku, Tokyo), in collaboration with Tokyo Medical and Dental University and other institutions, has determined from the results of whole-exome sequencing of 296 Japanese patients with lung adenocarcinoma, including 54 cases complicated by interstitial pneumonia, that mutations in the Pulmonary Surfactant System Genes are characteristic of lung adenocarcinoma complicated by interstitial pneumonia and that the group with these mutations has a poor prognosis. The research findings were published in "Journal of Clinical Oncology Precision Medicine," a journal of the American Society of Clinical Oncology, on August 17.
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