Director: Shigeru Koh (Associate Professor, School of Medicine)
Main Campus: Shinanomachi
Center Overview
The Center for Systems Medical Research and Development organizes cross-faculty research teams from the School of Medicine, Faculty of Science and Technology, Faculty of Environment and Information Studies, and other faculties. In cooperation with participating companies, we will develop technologies to build a next-generation medical ICT platform that enables the comprehensive integration, sharing, and analysis of medical information. We will also develop medical and healthcare systems that contribute to further extending the healthy life expectancy of the nation by making maximum use of the vast amount of medical information obtained through comprehensive molecular and imaging analysis technologies for individual healthcare. We will disseminate these results to the world and contribute to the realization of an ideal, vibrant society of 100-year healthy life expectancy (a centenarian society).
Keywords and Main Research Themes
Healthy longevity, centenarian society, next-generation medical ICT platform, genomic medicine, systems medicine
Fiscal Year 2019 Business Plan
■ Continuing Activities from FY2018: Background, Rationale, and Goals
In FY2019, we will continue our shared research for the AMED "Project for Innovative Drug Discovery Technology through the Use of Glycans." We will also continue preparations for the specimen management system to begin actual operation within FY2019 (Shigeru Koh).
Telemedicine is finally entering the stage of social implementation as a form of health and medical care. Telemedicine is a medical format with high affinity for the databasing of medical information, and through its promotion, we hope to contribute to facilitating the construction of a next-generation medical ICT platform (Taishiro Kishimoto).
We have achieved many results from our research to date. In FY2019, we will continue to promote the development of new test items, the selection of new test items, research to confirm their clinical usefulness, and joint research with various clinical departments, including clinical laboratory medicine (Mitsuru Murata).
By utilizing the various mass spectrometry technologies in our department, we will continue to clarify the metabolic characteristics of cancer and immune cells and identify the "points of action" for their respective metabolic remodeling (Takehiro Yamamoto).
■ New Activity Goals and Content for FY2019, and Background for Implementation
In FY2019, we will continue our activities to introduce the specimen management system at Keio University Hospital (Shigeru Koh).
We will continue the development of the glycan analysis system (Shigeru Koh).
I will become a member of the preparatory committee for telemedicine in the psychiatric field and will make adjustments for its social implementation (Taishiro Kishimoto).
The School of Medicine and the hospital are working together on an on-campus specimen banking system. We will prepare the laboratory side to handle its actual operation (Mitsuru Murata).
From this fiscal year's research results, we have identified multiple specific molecular vibration signals in cancerous and non-cancerous areas through Raman spectroscopic analysis of clinical specimens. In FY2019, we will proceed with the identification of these molecules and aim to search for marker molecules that correlate with the efficacy of chemotherapy (Takehiro Yamamoto).
Fiscal Year 2019 Business Report
■ Implementation Details for the Fiscal Year Business Plan, Research Results, and Degree of Achievement
Introduction and operation of the specimen management system at Keio University Hospital: We are preparing to introduce the program developed in FY2015 at Keio University Hospital for use in actual clinical settings. In FY2019, we held monthly meetings of the Specimen Management Support Division Working Group to prepare for the future introduction of the specimen management system at Keio Hospital.
Glycan analysis research: We are conducting research for the Japan Agency for Medical Research and Development (AMED) FY2017 "Project for Innovative Drug Discovery Technology through the Use of Glycans," under the research and development proposal (1) "Construction of a Multifaceted Glycan Analysis System for Target Molecule Discovery and Validation, Leveraging Japan's Technological Strengths and a Close Industry-Academia-Medical Collaboration" (Principal Investigator: Koyu Sakamoto). Keio University is one of the two core research centers for this project, along with AIST (Tsukuba), and plays an important role in the clinical application of this project. We continued our research activities in FY2019 (Shigeru Koh).
AMED-commissioned research on telepsychiatry: We conducted research for the ICT Infrastructure Development for Clinical Research Project, Medical Digital Revolution Realization Project, on "Guideline Development and Database Construction for Data Utilization through the Accumulation of Clinical Research Evidence in Telepsychiatry" (Taishiro Kishimoto).
Development of new test items, selection of new test items, research to confirm clinical usefulness, and joint research with clinical departments including clinical laboratory medicine: We provide research support through the creation of test data and specialized knowledge. Research results were obtained and disseminated both domestically and internationally in areas such as the development of sample collection methods and information management systems for clinical research, practical testing methods for minimal residual disease in malignant tumors and their efficiency and standardization, automation and standardization of urinalysis, development and dissemination of POCT (point-of-care testing), promotion of domestic and international external quality control and quality assurance, DNA methylation quantitative analysis by LC-MS/MS, development of urinary steroid metabolite analysis, and development of microbial genetic diagnostic methods, especially fully automated genetic testing equipment (Mitsuru Murata).
Metabolome analysis research: This fiscal year, we revealed that the sulfur-containing amino acid metabolite hypotaurine contributes to the oxidative stress resistance of colon cancer cells. We also established a detection system for hydrogen persulfide, which also acts as an electrophile within tumors. Using a combination of trans-omics technologies—including metabolome analysis using CE-MS, expression analysis of metabolic enzyme groups, and sulfur compound imaging technology with Raman microscopy—on various cell lines and clinical specimens, we are investigating the metabolic profiling of cancerous and non-cancerous areas to explore the novel effects of sulfur compounds in the acquisition of malignant traits in cancer (Takehiro Yamamoto).
Achievements in Social Contribution, including Published Papers, Conference Presentations, and Events
Published papers: 6
J Telemed Telecare, J Affect Disord, et al.
Number of conference presentations (domestic and international): 29 (24 domestic, 5 international)
Achievements in social contribution, such as events
Initiatives for AI Utilization in Psychiatry, Medical x AI Seminar Series, June 15, 2019, 6th Symposium "Implementation and Trust of Medical AI in Clinical Practice," Tokyo, SMBC Academia Hall, The University of Tokyo, Hongo Campus
Introduction Process and Guideline Formulation for Telepsychiatry, and an Attempt to Quantify Psychiatric Symptoms Using Machine Learning, July 10, 2019, 21st Century Medical Forum, 4th Healthcare Subcommittee Meeting, Tokyo, TKP Shinbashi Conference Center Annex
IoT Healthy Life Research in a Super-Aged Society, December 13, 2019, The 20th KEIO TECHNO-MALL 2019, Tokyo, Tokyo International Forum
Development of New Treatment Support and Prevention Technologies in the Psychiatric Field Utilizing Information and Communication Technology, January 31, 2020, FY2019 Next-Generation Medical Device Collaboration Hub Equipment Project Symposium, Tokyo, Station Conference Tokyo
Project Members
Principal Investigator
Shigeru Koh
Associate ProfessorThe Sakaguchi Laboratory (Systems Medicine), School of MedicineMasayuki Amagai
ProfessorDepartment of Dermatology, School of Medicine